THE CENTRE FOR PHENOGENOMICS (TCP)

The Centre for Phenogenomics (TCP) is a state-of-the-art research centre enabling groundbreaking research and discovery, with the goal of advancing human health. We are the largest Centre in Canada, brought about through an innovative scientific collaboration among preeminent research hospitals including Mount Sinai Hospital and The Hospital for Sick Children. The TCP is a globally acclaimed Canadian resource that serves researchers throughout the world. Located in the heart of Toronto’s Discovery District, the TCP pools functional expertise and resources under one roof, all to enable the best science, supported by the best infrastructure. Our ability to generate, hold, analyze, archive and distribute a critical mass of genetically engineered mice is unique. Your significant contributions will assist in maintaining our momentum in advancing our research.

TCP has an immediate opening for a full-time Transgenic Technologist with weekend and stat holiday availability working 37.5 hours per week. Reporting to the Associate Director, Model Production Core (Transgenic Team) the incumbent will contribute to the production of genetically modified mouse models by preparing embryo donors and recipients, breeding, weaning, mouse colony management, and other technical assistance to support the operation of the Model Production Core. The work is conducted in a highly regulated environment according to Standard Operating Procedures.

Role and Responsibilities:

• Preparation of mouse embryo donors and recipients for transgenic services, including:
  • Selecting estrus stage in female mice
  • Checking copulation plugs for timed pregnancies
  • Intraperitoneal injection of hormones to superovulate embryo donors
• Mouse identification and tissue biopsy
• Maintenance of mouse colonies, including breeding and weaning
• Data entry into databases and laboratory records
• Caesarian section and cross-fostering neonate pups
• Vasectomy
• Preparing media and reagents
• Mouse embryonic stem (ES) cell culture
• Other duties as required

Requirements

• Bachelor’s degree in Biology, Developmental Biology or related discipline or Veterinary Technician Diploma.
• Experience with laboratory research animals.
• Demonstrated experience as a self-motivated, responsible person, able to work in both as a member of a team and independently with minimal supervision.
• Demonstrated excellent English communication (both written and verbal), interpersonal and organizational skills.
• Demonstrated willingness and ability to learn new techniques, solve technical problems, and troubleshoot standard protocols.
• Demonstrated excellent work ethic, professional attitude, and high standards for accuracy.
• Demonstrated close attention to detail and ability to accurately follow protocols, document work, and record data.
• Ability to meet deadlines and adapt to changes in schedules and priorities.
• Available to work weekends and stat holidays.

Preferred

• Registered Laboratory Animal Technician (CALAS) or working towards certification.
• Familiarity with CCAC guidelines relevant to working with animals in research.
• Experience with mammalian cell culture.
• Experience with mammalian embryo manipulation, including microinjections and embryo transfer surgeries.

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases. All employees and affiliates will follow safe work practices and comply with health and safety policies, procedures, and training. Successful candidates will be required to provide two (2) written reference letters from their former employer(s)/supervisor(s).

To ensure the safety and wellbeing of all our people and patients, Sinai Health has made it a priority to support everyone in getting vaccinated against COVID-19. Consistent with this, our Staff Immunization & Surveillance Policy was recently updated to include the requirement for full vaccination – currently defined as receiving two doses and serving a 14-day waiting period following the second dose – in order to be able to work at Sinai Health. To be compliant with our updated Policy, you must provide proof of dual COVID-19 vaccination, as indicated on the Prospective Immunization and Surveillance Policy Information Sheet, in order to be eligible for employment at Sinai Health. If you believe you are one of the very few people who may require an exemption from vaccination, supporting medical information must be submitted to our Occupational Health department, who will review and assess.

We are a fully committed to fairness and equity in employment and our recruitment and selection practices. We encourage applications from Indigenous peoples, people with disabilities, members of sexual minority groups, members of racialized groups, women and any others who may contribute to the further diversification of our Sinai Health community. Accommodation will be provided in all parts of the hiring process as required under our Access for People with Disabilities policy. Applicants need to make their requirements known in advance.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment, and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.

Hours: 37.5 hrs. per week / weekends

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